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Antitumor Agents 286. Design, Synthesis and Structure-Activity Relationships of 3′R,4′R-Disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DSP) Analogs as Potent Chemosensitizers to Overcome Multidrug Resistance

In this study, various 3′R,4′R-disubstituted-2′,2′-dimethydihydropyrano[2,3-f]chromone (DSP) derivatives were discovered as potent chemosensitizers in the treatment of multidrug resistant cancer cells. Twenty-four DSP analogs (5–28) were synthesized and evaluated against a multi-drug resistant (MDR)...

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Bibliografiske detaljer
Main Authors: Zhou, Ting, Shi, Qian, Bastow, Kenneth F., Lee, Kuo-Hsiung
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074582/
https://ncbi.nlm.nih.gov/pubmed/21082774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101249z
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