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Polyglutamine toxicity in non-neuronal cells

The neurodegenerative polyglutamine diseases are caused by an expansion of unstable polyglutamine repeats in various disease proteins. Although these mutant proteins are expressed ubiquitously in neuronal and non-neuronal cells, they cause selective degeneration of specific neuronal populations. Rec...

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Detalhes bibliográficos
Main Authors: Bradford, Jennifer W, Li, Shihua, Li, Xiao-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074229/
https://ncbi.nlm.nih.gov/pubmed/20231860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.32
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