Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. The present study was designed to determine whether any of the recently identified PDEs (PDE7-PDE11) contribute to progressive pulmonary vascular...

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Hlavní autoři: Tian, Xia, Vroom, Christina, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Bieniek, Ewa, Grimminger, Friedrich, Seeger, Werner, Schermuly, Ralph Theo, Pullamsetti, Soni Savai
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073929/
https://ncbi.nlm.nih.gov/pubmed/21494592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018136
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