Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. The present study was designed to determine whether any of the recently identified PDEs (PDE7-PDE11) contribute to progressive pulmonary vascular...

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Detalhes bibliográficos
Main Authors: Tian, Xia, Vroom, Christina, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Bieniek, Ewa, Grimminger, Friedrich, Seeger, Werner, Schermuly, Ralph Theo, Pullamsetti, Soni Savai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073929/
https://ncbi.nlm.nih.gov/pubmed/21494592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018136
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