Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration

BACKGROUND: The aim of the study was to assess the chronic effects of combined phosphodiesterase 3/4 inhibitor tolafentrine, administered by inhalation, during monocrotaline-induced pulmonary arterial hypertension (PAH) in rats. METHODS: CD rats were given a single subcutaneous injection of monocrot...

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Autores principales: Pullamsetti, Soni, Krick, Stefanie, Yilmaz, Hüseyin, Ghofrani, Hossein Ardeschir, Schudt, Christian, Weissmann, Norbert, Fuchs, Beate, Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph Theo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291406/
https://ncbi.nlm.nih.gov/pubmed/16262900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-6-128
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