Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

RATIONALE: Chronic obstructive pulmonary disease (COPD) is a widespread disease, with no curative therapies available. Recent findings suggest a key role of NO and sGC-cGMP signaling for the pathogenesis of the disease. Previous data suggest a downregulation/inactivation of the cGMP producing solubl...

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Udgivet i:PLoS One
Main Authors: Seimetz, Michael, Parajuli, Nirmal, Pichl, Alexandra, Bednorz, Mariola, Ghofrani, Hossein Ardeschir, Schermuly, Ralph Theo, Seeger, Werner, Grimminger, Friedrich, Weissmann, Norbert
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461257/
https://ncbi.nlm.nih.gov/pubmed/26058042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129327
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