Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways

To understand relationships between phosphorylation-based signaling pathways, we analyzed 150 deletion mutants of protein kinases and phosphatases in S. cerevisiae using DNA microarrays. Downstream changes in gene expression were treated as a phenotypic readout. Double mutants with synthetic genetic...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: van Wageningen, Sake, Kemmeren, Patrick, Lijnzaad, Philip, Margaritis, Thanasis, Benschop, Joris J., de Castro, Inês J., van Leenen, Dik, Koerkamp, Marian J.A. Groot, Ko, Cheuk W., Miles, Antony J., Brabers, Nathalie, Brok, Mariel O., Lenstra, Tineke L., Fiedler, Dorothea, Fokkens, Like, Aldecoa, Rodrigo, Apweiler, Eva, Taliadouros, Virginia, Sameith, Katrin, van de Pasch, Loes A.L., van Hooff, Sander R., Bakker, Linda V., Krogan, Nevan J., Snel, Berend, Holstege, Frank C.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073509/
https://ncbi.nlm.nih.gov/pubmed/21145464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.021
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky