Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways

To understand relationships between phosphorylation-based signaling pathways, we analyzed 150 deletion mutants of protein kinases and phosphatases in S. cerevisiae using DNA microarrays. Downstream changes in gene expression were treated as a phenotypic readout. Double mutants with synthetic genetic...

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Autors principals: van Wageningen, Sake, Kemmeren, Patrick, Lijnzaad, Philip, Margaritis, Thanasis, Benschop, Joris J., de Castro, Inês J., van Leenen, Dik, Koerkamp, Marian J.A. Groot, Ko, Cheuk W., Miles, Antony J., Brabers, Nathalie, Brok, Mariel O., Lenstra, Tineke L., Fiedler, Dorothea, Fokkens, Like, Aldecoa, Rodrigo, Apweiler, Eva, Taliadouros, Virginia, Sameith, Katrin, van de Pasch, Loes A.L., van Hooff, Sander R., Bakker, Linda V., Krogan, Nevan J., Snel, Berend, Holstege, Frank C.P.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073509/
https://ncbi.nlm.nih.gov/pubmed/21145464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.021
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