A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions

BACKGROUND: Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these genetic interactions has hardly been characterized. Understanding the molecular basis of genetic interactions is crucial in deciphering...

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Veröffentlicht in:BMC Biol
Hauptverfasser: Sameith, Katrin, Amini, Saman, Groot Koerkamp, Marian J. A., van Leenen, Dik, Brok, Mariel, Brabers, Nathalie, Lijnzaad, Philip, van Hooff, Sander R., Benschop, Joris J., Lenstra, Tineke L., Apweiler, Eva, van Wageningen, Sake, Snel, Berend, Holstege, Frank C. P., Kemmeren, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690272/
https://ncbi.nlm.nih.gov/pubmed/26700642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-015-0222-5
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