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Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).

The toxicity and mutagenicity of three DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin) were investigated in Escherichia coli. The adducts studied were cis-[Pt(NH3)2(d(GpG))] (G*G*), cis-[Pt(NH3)2(d(ApG))] (A*G*) and cis-[Pt(NH3)2(d(GpTpG))] (G*TG*),...

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Autori principali: Yarema, K J, Lippard, S J, Essigmann, J M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC307344/
https://ncbi.nlm.nih.gov/pubmed/7479066
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