Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).

The toxicity and mutagenicity of three DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin) were investigated in Escherichia coli. The adducts studied were cis-[Pt(NH3)2(d(GpG))] (G*G*), cis-[Pt(NH3)2(d(ApG))] (A*G*) and cis-[Pt(NH3)2(d(GpTpG))] (G*TG*),...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Yarema, K J, Lippard, S J, Essigmann, J M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1995
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307344/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.20.4066
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