Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate.

To enhance the resistance of 2-5A (pppA2'p5'A2'p5'A) to degradation by exo- and endonucleases, a phosphorodithioate analog was synthesized using a solid-phase phosphite triester approach with N6-benzoyl-5'-O-dimethoxytrityl-3'-O-t-butyldimethylsilyladenosine 2'-[S-(beta-thiobenzoylethyl)-pyrrolidino...

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Publicado en:	Nucleic Acids Res
Autores principales:	Beigelman, L, Matulic-Adamic, J, Haeberli, P, Usman, N, Dong, B, Silverman, R H, Khamnei, S, Torrence, P F
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1995
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.19.3989
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