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Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate.

To enhance the resistance of 2-5A (pppA2'p5'A2'p5'A) to degradation by exo- and endonucleases, a phosphorodithioate analog was synthesized using a solid-phase phosphite triester approach with N6-benzoyl-5'-O-dimethoxytrityl-3'-O-t-butyldimethylsilyladenosine 2'-[S-...

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Detalles Bibliográficos
Main Authors: Beigelman, L, Matulic-Adamic, J, Haeberli, P, Usman, N, Dong, B, Silverman, R H, Khamnei, S, Torrence, P F
Formato: Artigo
Idioma:Inglês
Publicado: 1995
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC307321/
https://ncbi.nlm.nih.gov/pubmed/7479047
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