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Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17
Oncogenic mutations in Kras occur in 40%-45% of patients with advanced colorectal cancer (CRC). We have previously shown that chemotherapy acutely activates ADAM17 resulting in growth factor shedding, growth factor receptor activation and drug resistance in CRC tumours. In this study, we examined th...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3073126/ https://ncbi.nlm.nih.gov/pubmed/21148749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0714 |
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