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Higher Intensity of Purifying Selection on >90% of the Human Genes Revealed by the Intrinsic Replacement Mutation Rates
For over 3 decades, the rate of replacement mutations has been assumed to be equal to, and estimated from, the rate of “strictly” neutral sequence divergence in noncoding regions and in silent-codon positions where mutations do not alter the amino acid encoded. This assumption is fundamental to esti...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072915/ https://ncbi.nlm.nih.gov/pubmed/16982819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msl123 |
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