Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

Inflammation stimulates immunity but can create immune privilege in some settings. Here, we show that cutaneous Leishmania major infection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes. Induced IDO attenuated the T cell stimulatory funct...

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Bibliografiska uppgifter
Huvudupphovsmän: Makala, Levi H. C., Baban, Babak, Lemos, Henrique, El-Awady, Ahmed R., Chandler, Phillip R., Hou, De-Yan, Munn, David H., Mellor, Andrew L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
Ämnen:
Major Articles and Brief Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072725/
https://ncbi.nlm.nih.gov/pubmed/21282196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq095
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