Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

Inflammation stimulates immunity but can create immune privilege in some settings. Here, we show that cutaneous Leishmania major infection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes. Induced IDO attenuated the T cell stimulatory funct...

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Dettagli Bibliografici
Autori principali: Makala, Levi H. C., Baban, Babak, Lemos, Henrique, El-Awady, Ahmed R., Chandler, Phillip R., Hou, De-Yan, Munn, David H., Mellor, Andrew L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072725/
https://ncbi.nlm.nih.gov/pubmed/21282196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq095
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