Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

Inflammation stimulates immunity but can create immune privilege in some settings. Here, we show that cutaneous Leishmania major infection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes. Induced IDO attenuated the T cell stimulatory funct...

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Detalles Bibliográficos
Main Authors: Makala, Levi H. C., Baban, Babak, Lemos, Henrique, El-Awady, Ahmed R., Chandler, Phillip R., Hou, De-Yan, Munn, David H., Mellor, Andrew L.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072725/
https://ncbi.nlm.nih.gov/pubmed/21282196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq095
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