Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

Inflammation stimulates immunity but can create immune privilege in some settings. Here, we show that cutaneous Leishmania major infection stimulated expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes. Induced IDO attenuated the T cell stimulatory funct...

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Bibliografiske detaljer
Main Authors: Makala, Levi H. C., Baban, Babak, Lemos, Henrique, El-Awady, Ahmed R., Chandler, Phillip R., Hou, De-Yan, Munn, David H., Mellor, Andrew L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072725/
https://ncbi.nlm.nih.gov/pubmed/21282196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiq095
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