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Traveling Bax and Forth from Mitochondria to Control Apoptosis
Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found primarily in the cytosol. In this issue, Edlich et al., (2011) show that Bax and Bcl-xL interact on the mitochondrial surface and then retrotranslocate to the cytosol, effectively preventing Bax-indu...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cell Press
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072571/ https://ncbi.nlm.nih.gov/pubmed/21458662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.025 |
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