Repeated administration of the GABA(B) receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats

RATIONALE: γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain and is implicated in the modulation of central reward processes. Acute or chronic administration of GABA(B) receptor agonists or positive modulators decreased self-administration of various drugs of abuse. Fu...

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Autors principals: Vlachou, Styliani, Guery, Sebastien, Froestl, Wolfgang, Banerjee, Deboshri, Benedict, Jessica, Finn, M. G., Markou, Athina
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2010
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072487/
https://ncbi.nlm.nih.gov/pubmed/21181127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-2119-x
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