Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

The nucleotide-binding and oligomerization, leucine-rich repeat (NLR) family of proteins sense microbial infections and activate the inflammasome, a multi-protein complex that promotes microbial clearance. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several human malignancies. W...

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Main Authors: Gregory, Sean M., Davis, Beckley K., West, John A., Taxman, Debra J., Matsuzawa, Shu-ichi, Reed, John C., Ting, Jenny P.Y., Damania, Blossom
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072027/
https://ncbi.nlm.nih.gov/pubmed/21252346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1199478
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