A Pharmacodynamic Study of Docetaxel in Combination with the P-glycoprotein Antagonist, Tariquidar (XR9576) in Patients with Lung, Ovarian, and Cervical Cancer

PURPOSE: P-glycoprotein (Pgp) antagonists have been difficult to develop because of complex pharmacokinetic interactions and a failure to demonstrate meaningful results. Here we report the results of a pharmacokinetic and pharmacodynamic trial using a third generation, potent, non-competitive inhibi...

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Päätekijät: Kelly, Ronan J., Draper, Deborah, Chen, Clara C., Robey, Robert W., Figg, William D., Piekarz, Richard L., Chen, Xiaohong, Gardner, Erin R., Balis, Frank M., Venkatesan, Aradhana M., Steinberg, Seth M., Fojo, Tito, Bates, Susan E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071989/
https://ncbi.nlm.nih.gov/pubmed/21081657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1725
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