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The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein
1. The kinetics and nature of equilibrium binding were used to characterize the molecular interaction of the anthranilic acid derivative [(3)H]-XR9576 with the multidrug resistance P-glycoprotein (P-gp). XR9576 displayed specific high-affinity binding to P-gp (B(max)=275 pmol mg(−1), K(d)=5.1 nM). T...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571648/ https://ncbi.nlm.nih.gov/pubmed/10510451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702807 |
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