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The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction
1. The interaction of the indolizin sulfone SR33557 with the multidrug resistance P-glycoprotein (P-gp), was used to explore the nature of drug binding site(s) on this transporter. The steady-state accumulation of [(3)H]-vinblastine in P-gp expressing CH(r)B30 cells was increased by SR33557 with gre...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564986/ https://ncbi.nlm.nih.gov/pubmed/9375975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701429 |
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