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Age-dependent expression of MeCP2 in a heterozygous mosaic mouse model

Functional deficiency of the X-linked methyl-CPG binding protein 2 (MeCP2) leads to the neurodevelopmental disorder Rett syndrome (RTT). Due to random X-chromosome inactivation (XCI), most RTT patients are females who are heterozygous for the MECP2 mutation and therefore mosaic in MeCP2 deficiency....

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Detalhes bibliográficos
Main Authors: Smrt, Richard D., Pfeiffer, Rebecca L., Zhao, Xinyu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071674/
https://ncbi.nlm.nih.gov/pubmed/21330301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr066
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