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Co-existence of circular and multiple linear amplicons in methotrexate-resistant Leishmania.

Circular and linear amplicons were analyzed in detail in Leishmania tropica cells resistant to methotrexate (MTX). Both types of elements presented sequences related to the H locus and coexisted in resistant cells. The linear amplicons appeared first during the selection process (at 10 microM MTX) a...

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Main Authors: Olmo, A, Arrebola, R, Bernier, V, González-Pacanowska, D, Ruiz-Pérez, L M
Format: Artigo
Jezik:Inglês
Izdano: 1995
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC307122/
https://ncbi.nlm.nih.gov/pubmed/7659507
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