Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma

Medulloblastoma is the most common pediatric malignant brain tumor, arising from aberrant cerebellar precursors' development, a process mainly controlled by Hedgehog (Hh) signaling pathway. Histone deacetylase HDAC1 has been recently shown to modulate Hh signaling, deacetylating its effectors G...

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Hlavní autoři: De Smaele, Enrico, Di Marcotullio, Lucia, Moretti, Marta, Pelloni, Marianna, Occhione, Maria Anna, Infante, Paola, Cucchi, Danilo, Greco, Azzura, Pietrosanti, Laura, Todorovic, Jelena, Coni, Sonia, Canettieri, Gianluca, Ferretti, Elisabetta, Bei, Roberto, Maroder, Marella, Screpanti, Isabella, Gulino, Alberto
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071086/
https://ncbi.nlm.nih.gov/pubmed/21472142
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