The A/G Allele of Rs16906252 Predicts for MGMT Methylation and Is Selectively Silenced in Premalignant Lesions from Smokers and in Lung Adenocarcinomas

PURPOSE: To address the association between sequence variants within the MGMT promoter-enhancer region and methylation of MGMT in premalignant lesions from smokers and lung adenocarcinomas, their biological effects on gene regulation, and targeting MGMT for therapy. EXPERIMENTAL DESIGN: SNPs identif...

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Main Authors: Leng, Shuguang, Bernauer, Amanda M., Hong, Chibo, Do, Kieu C., Yingling, Christin M., Flores, Kristina G., Tessema, Mathewos, Tellez, Carmen S., Willink, Randall P., Burki, Elizabeth A., Picchi, Maria A., Stidley, Christine A., Prados, Michael D., Costello, Joseph F., Gilliland, Frank D., Crowell, Richard E., Belinsky, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070839/
https://ncbi.nlm.nih.gov/pubmed/21355081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3026
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