GATA2 is epigenetically repressed in human and mouse lung tumors and is not requisite for survival of KRAS mutant lung cancer

INTRODUCTION: GATA2 was recently described as a critical survival factor and therapeutic target for KRAS mutant non-small cell lung cancer (NSCLC). However, whether this role is affected by epigenetic repression of GATA2 in lung cancer is unclear. METHODS: GATA2 expression and promoter CpG island me...

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Main Authors: Tessema, Mathewos, Yingling, Christin M., Snider, Amanda M., Do, Kieu, Juri, Daniel E., Picchi, Maria A., Zhang, Xiequn, Liu, Yushi, Leng, Shuguang, Tellez, Carmen S., Belinsky, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132640/
https://ncbi.nlm.nih.gov/pubmed/24807155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000165
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