EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells

Epithelial mesenchymal transition (EMT) is strongly associated with cancer progression, but its potential role during premalignant development has not been studied. Here we show that a four-week exposure of immortalized human bronchial epithelial cells (HBECs) to tobacco carcinogens can induce a per...

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Autores principales: Tellez, Carmen S., Juri, Daniel E., Do, Kieu, Bernauer, Amanda M., Thomas, Cindy L., Damiani, Leah A., Tessema, Mathewos, Leng, Shuguang, Belinsky, Steven A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078195/
https://ncbi.nlm.nih.gov/pubmed/21363915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3035
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