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EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells

Epithelial mesenchymal transition (EMT) is strongly associated with cancer progression, but its potential role during premalignant development has not been studied. Here we show that a four-week exposure of immortalized human bronchial epithelial cells (HBECs) to tobacco carcinogens can induce a per...

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Detalhes bibliográficos
Main Authors: Tellez, Carmen S., Juri, Daniel E., Do, Kieu, Bernauer, Amanda M., Thomas, Cindy L., Damiani, Leah A., Tessema, Mathewos, Leng, Shuguang, Belinsky, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078195/
https://ncbi.nlm.nih.gov/pubmed/21363915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3035
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