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Linear ubiquitin assembly complex negatively regulates RIG-I and TRIM25 mediated type-I interferon induction
Upon detection of viral RNA, retinoic acid inducible gene I (RIG-I) undergoes TRIM25-mediated Lys-63 linked ubiquitination, leading to type-I interferon (IFN) production. In this study, we demonstrate that the linear ubiquitin assembly complex (LUBAC), comprised of two RING-IBR-RING (RBR)-containing...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070481/ https://ncbi.nlm.nih.gov/pubmed/21292167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.12.029 |
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