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Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I
TRIM25 mediates Lys 63-linked ubiquitination of the N-terminal CARDs of the viral RNA sensor RIG-I, leading to type I interferon (IFN) production. Here, we report that the influenza A virus non-structural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppre...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737813/ https://ncbi.nlm.nih.gov/pubmed/19454348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2009.04.006 |
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