Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I

TRIM25 mediates Lys 63-linked ubiquitination of the N-terminal CARDs of the viral RNA sensor RIG-I, leading to type I interferon (IFN) production. Here, we report that the influenza A virus non-structural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppre...

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Autors principals: Gack, Michaela Ulrike, Albrecht, Randy Allen, Urano, Tomohiko, Inn, Kyung-Soo, Huang, I-Chueh, Carnero, Elena, Farzan, Michael, Inoue, Satoshi, Jung, Jae Ung, García-Sastre, Adolfo
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737813/
https://ncbi.nlm.nih.gov/pubmed/19454348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2009.04.006
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