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COUPLING OF V(D)J RECOMBINATION TO THE CELL CYCLE SUPPRESSES GENOMIC INSTABILITY AND LYMPHOID TUMORIGENESIS
V(D)J gene segment recombination is linked to the cell cycle by the periodic phosphorylation and destruction of the RAG-2 protein at the G1-to-S cell cycle transition. To examine the function of this coupling, we constructed mice in which the phosphorylation site at threonine 490 of RAG-2 was mutate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070474/ https://ncbi.nlm.nih.gov/pubmed/21349429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.02.003 |
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