Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inheri...

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Detalhes bibliográficos
Main Authors: Kittiniyom, Kanokwan, Gorse, Karen M, Dalbegue, Fabienne, Lichy, Jack H, Taubenberger, Jeffery K, Newsham, Irene F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2001
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30703/
https://ncbi.nlm.nih.gov/pubmed/11305954
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