Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends.
The Ku complex binds non-specifically to DNA breaks and ensures repair via NHEJ. However, Ku is also known to bind directly to telomeric DNA ends and its presence there is associated with telomere capping, but avoiding NHEJ. How the complex discriminates between a DNA break and a telomeric extremity...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2016-12-01
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| Серии: | PLoS Genetics |
| Online-ссылка: | http://europepmc.org/articles/PMC5145143?pdf=render |
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