Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic anticonvulsants such as phenobarbital. We now report that, in intact...

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Main Authors: Dzhala, Volodymyr I., Kuchibhotla, Kishore V., Glykys, Joseph C., Kahle, Kristopher T., Swiercz, Waldemar B., Feng, Guoping, Kuner, Thomas, Augustine, George J., Bacskai, Brian J., Staley, Kevin J.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2010
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070296/
https://ncbi.nlm.nih.gov/pubmed/20810895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1769-10.2010
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