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Interactions of APE1 with a redox inhibitor: Evidence for an alternate conformation of the enzyme
Apurinic/apyrimidinic endonuclease (APE1) is an essential base excision repair protein that also functions as a reduction/oxidation (redox) factor in mammals. Through a thiol-based mechanism, APE1 reduces a number of important transcription factors including AP-1, p53, NF-κB, and HIF-1α. What is kno...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070192/ https://ncbi.nlm.nih.gov/pubmed/21117647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101248s |
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