Interactions of APE1 with a redox inhibitor: Evidence for an alternate conformation of the enzyme

Apurinic/apyrimidinic endonuclease (APE1) is an essential base excision repair protein that also functions as a reduction/oxidation (redox) factor in mammals. Through a thiol-based mechanism, APE1 reduces a number of important transcription factors including AP-1, p53, NF-κB, and HIF-1α. What is kno...

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Bibliographic Details
Main Authors: Su, Dian, Delaplane, Sarah, Luo, Meihua, Rempel, Don L., Vu, Bich, Kelley, Mark R., Gross, Michael L., Georgiadis, Millie M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070192/
https://ncbi.nlm.nih.gov/pubmed/21117647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101248s
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