CD28 Costimulation Impairs the Efficacy of a Redirected T-cell Antitumor Attack in the Presence of Regulatory T cells Which Can Be Overcome by Preventing Lck Activation

Adoptive T-cell transfer showed promising efficacy in recent trials raising interest in T cells with redirected specificity against tumors. T cells were engineered with a chimeric antigen receptor (CAR) with predefined binding and CD3ζ signaling to initiate T-cell activation. CD28 costimulation prov...

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Autors principals: Kofler, David M, Chmielewski, Markus, Rappl, Gunter, Hombach, Anja, Riet, Tobias, Schmidt, Annette, Hombach, Andreas A, Wendtner, Clemens-Martin, Abken, Hinrich
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070115/
https://ncbi.nlm.nih.gov/pubmed/21326215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.9
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