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Theory and simulation on the kinetics of protein–ligand binding coupled to conformational change

Conformational change during protein–ligand binding may significantly affect both the binding mechanism and the rate constant. Most earlier theories and simulations treated conformational change as stochastic gating with transition rates between reactive and nonreactive conformations uncoupled to li...

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Hlavní autoři: Cai, Lu, Zhou, Huan-Xiang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Institute of Physics 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069985/
https://ncbi.nlm.nih.gov/pubmed/21405192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3561694
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