Targeting the PI3K/mTOR Pathway in Murine Endocrine Cell Lines: In Vitro and in Vivo Effects on Tumor Cell Growth

The mammalian target of rapamycin (mTOR) inhibitors, such as rapalogues, are a promising new tool for the treatment of metastatic gastroenteropancreatic endocrine tumors. However, their mechanisms of action remain to be established. We used two murine intestinal endocrine tumoral cell lines, STC-1 a...

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Detalhes bibliográficos
Main Authors: Couderc, Christophe, Poncet, Gilles, Villaume, Karine, Blanc, Martine, Gadot, Nicolas, Walter, Thomas, Lepinasse, Florian, Hervieu, Valérie, Cordier-Bussat, Martine, Scoazec, Jean-Yves, Roche, Colette
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069842/
https://ncbi.nlm.nih.gov/pubmed/21224070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2010.11.023
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