mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines

mTOR and Unfolded Protein Response (UPR) are two signaling pathways frequently activated in cancer cells. The mTOR pathway has been shown to be up-regulated in most gastroenteropancreatic neuroendocrine tumors. In contrast, little is known about the UPR status in neoplastic neuroendocrine cells. How...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Freis, Patricia, Bollard, Julien, Lebeau, Justine, Massoma, Patrick, Fauvre, Joëlle, Vercherat, Cécile, Walter, Thomas, Manié, Serge, Roche, Colette, Scoazec, Jean-Yves, Ferraro-Peyret, Carole
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400559/
https://ncbi.nlm.nih.gov/pubmed/28423496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15469
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