mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines

mTOR and Unfolded Protein Response (UPR) are two signaling pathways frequently activated in cancer cells. The mTOR pathway has been shown to be up-regulated in most gastroenteropancreatic neuroendocrine tumors. In contrast, little is known about the UPR status in neoplastic neuroendocrine cells. How...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Freis, Patricia, Bollard, Julien, Lebeau, Justine, Massoma, Patrick, Fauvre, Joëlle, Vercherat, Cécile, Walter, Thomas, Manié, Serge, Roche, Colette, Scoazec, Jean-Yves, Ferraro-Peyret, Carole
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400559/
https://ncbi.nlm.nih.gov/pubmed/28423496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15469
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