mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines

mTOR and Unfolded Protein Response (UPR) are two signaling pathways frequently activated in cancer cells. The mTOR pathway has been shown to be up-regulated in most gastroenteropancreatic neuroendocrine tumors. In contrast, little is known about the UPR status in neoplastic neuroendocrine cells. How...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Freis, Patricia, Bollard, Julien, Lebeau, Justine, Massoma, Patrick, Fauvre, Joëlle, Vercherat, Cécile, Walter, Thomas, Manié, Serge, Roche, Colette, Scoazec, Jean-Yves, Ferraro-Peyret, Carole
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400559/
https://ncbi.nlm.nih.gov/pubmed/28423496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15469
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