Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

The mammalian circadian clock component PERIOD2 (PER2) plays a critical role in circadian rhythm entrainment. Recently, a missense mutation at a putative phosphorylation site in hPER2, Ser-662, was identified in patients that suffer from familial advanced sleep phase syndrome (FASPS). Patients with...

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Detalhes bibliográficos
Main Authors: Shanware, Naval P., Hutchinson, John A., Kim, Sang Hwa, Zhan, Lihong, Bowler, Michael J., Tibbetts, Randal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069476/
https://ncbi.nlm.nih.gov/pubmed/21324900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.224014
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