Relationship between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly

Peptides and proteins possess an inherent propensity to self-assemble into generic fibrillar nanostructures known as amyloid fibrils, some of which are involved in medical conditions such as Alzheimer disease. In certain cases, such structures can self-propagate in living systems as prions and trans...

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Hlavní autoři: Wang, Yi-Qian, Buell, Alexander K., Wang, Xin-Yu, Welland, Mark E., Dobson, Christopher M., Knowles, Tuomas P. J., Perrett, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069414/
https://ncbi.nlm.nih.gov/pubmed/21233211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208934
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