Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

Ure2p is the protein determinant of the Saccharomyces cerevisiae prion state [URE3]. Constitutive overexpression of the HSP70 family member SSA1 cures cells of [URE3]. Here, we show that Ssa1p increases the lag time of Ure2p fibril formation in vitro in the presence or absence of nucleotide. The pre...

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Hoofdauteurs: Xu, Li-Qiong, Wu, Si, Buell, Alexander K., Cohen, Samuel I. A., Chen, Li-Jun, Hu, Wan-Hui, Cusack, Sarah A., Itzhaki, Laura S., Zhang, Hong, Knowles, Tuomas P. J., Dobson, Christopher M., Welland, Mark E., Jones, Gary W., Perrett, Sarah
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Royal Society 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638396/
https://ncbi.nlm.nih.gov/pubmed/23530260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0410
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