Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2

[Image: see text] The self-assembly of polypeptides into amyloid structures is associated with a range of increasingly prevalent neurodegenerative diseases as well as with a select set of functional processes in biology. The phenomenon of self-assembly results in species with dramatically different...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: Yang, Jie, Dear, Alexander J., Michaels, Thomas C. T., Dobson, Christopher M., Knowles, Tuomas P. J., Wu, Si, Perrett, Sarah
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2018
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880511/
https://ncbi.nlm.nih.gov/pubmed/29357227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b10439
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