Amyloid-Like Aggregates of the Yeast Prion Protein Ure2 Enter Vertebrate Cells by Specific Endocytotic Pathways and Induce Apoptosis

BACKGROUND: A number of amyloid diseases involve deposition of extracellular protein aggregates, which are implicated in mechanisms of cell damage and death. However, the mechanisms involved remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Here we use the yeast prion protein Ure2 as a gener...

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Bibliographic Details
Main Authors: Zhang, Chen, Jackson, Antony P., Zhang, Zai-Rong, Han, Yan, Yu, Shun, He, Rong-Qiao, Perrett, Sarah
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932714/
https://ncbi.nlm.nih.gov/pubmed/20824085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012529
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