HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair.
The hydrolytic deamination of 5-methylcytosine (5-mC) to thymine (T) is believed to be responsible for the high mutability of the CpG dinucleotide in DNA. We have shown a possible alternate mechanism for mutagenesis at CpG in which HpaII DNA-(cytosine-5) methyltransferase (M.HpaII) can enzymatically...
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| Izdano u: | Nucleic Acids Res |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
1995
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| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.8.1380 |
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