HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair.

The hydrolytic deamination of 5-methylcytosine (5-mC) to thymine (T) is believed to be responsible for the high mutability of the CpG dinucleotide in DNA. We have shown a possible alternate mechanism for mutagenesis at CpG in which HpaII DNA-(cytosine-5) methyltransferase (M.HpaII) can enzymatically...

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Main Authors: Yang, A S, Shen, J C, Zingg, J M, Mi, S, Jones, P A
格式: Artigo
語言:Inglês
出版: 1995
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC306865/
https://ncbi.nlm.nih.gov/pubmed/7753629
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