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A procedure for selective DNA alkylation and detection by mass spectrometry.

A method which improves the detectability of DNA by mass spectrometry is presented. By quantitatively alkylating the backbone of phosphorothioate oligonucleotides the problems of gas phase ion generation by matrix assisted laser desorption ionization can be controlled. We have developed a selective...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Gut, I G, Beck, S
Format: Artigo
Language:Inglês
Published: Oxford University Press 1995
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306863/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.8.1367
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