Measurement of the DNA Alkylating Agents Busulfan and Melphalan in Human Plasma by Mass Spectrometry

Busulfan and melphalan are cytotoxic DNA alkylating agents that are used in many hematopoietic stem cell transplantation (HCT) conditioning regimens. We report the development of an assay using turbulent flow liquid chromatography (TFLC) and tandem mass spectrometry to simultaneously measure the con...

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Publicado en:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Schofield, Ryan C., Landau, Heather J., Giralt, Sergio A., Shah, Gunjan, Scordo, Michael, Lin, Andrew, Zanutto, Elaine, Ramanathan, Lakshmi V., Pessin, Melissa S., Carlow, Dean C.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692901/
https://ncbi.nlm.nih.gov/pubmed/31376591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2019.121711
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